What is Embryo Glue? Who Uses It?

Embryo adhesive used in in vitro fertilization treatments helps create a strong and stable connection between the developing embryo and the inner lining of the uterus. You can read the rest of the text to learn more about embryo glue, which significantly increases the chances of successful implantation and pregnancy.

What is Embryo Glue?

Embryo adhesive is a special solution used in the field of assisted reproductive technology (ART) to increase the success of in vitro fertilization (IVF) procedures. This innovative substance is often referred to as “culture medium supplement” and plays a critical role in the delicate process of embryo transfer during IVF. What makes embryo glue special is its unique composition that closely mimics the natural environment of the uterus. It contains certain ingredients and high viscosity to create a positive microenvironment for the developing embryo. This promotes a strong and stable connection between the embryo and the uterine lining, ultimately increasing the chances of successful implantation and pregnancy.

The idea behind embryo glue is to provide a sticky quality that encourages the embryo to “stick” to the lining of the uterus, which is critical for successful implantation. By optimizing embryo transfer conditions, it minimizes the risk of embryo displacement and offers a higher probability of a successful connection. Thus, it reduces the possibility of implantation failure. This solution has proven particularly helpful for couples struggling with infertility, recurrent miscarriages, or unsuccessful IVF attempts.

The growing importance of embryo adhesive in the field of ART highlights its potential to revolutionize reproductive medicine and offers hope to individuals and couples dreaming of having children. However, it is important to remember that the effectiveness of embryo adhesive may vary from patient to patient and its use may depend on individual circumstances and medical recommendations.

How to Use Embryo Adhesive?

The use of embryo glue is a specific and controlled process usually performed by healthcare professionals during in vitro fertilization (IVF) procedures. General steps for using embryo adhesive can be listed as follows:

• Preparation: The use of embryo glue is part of the IVF protocol. Usually a female patient undergoes controlled ovarian stimulation to produce multiple eggs, which are then retrieved.
• Fertilization: Retrieved eggs are fertilized with sperm in the laboratory, either by traditional IVF or intracytoplasmic sperm injection (ICSI).
• Culturing Embryos: Fertilized eggs develop into embryos and are cultured in a special incubator under certain conditions.
• Selection of Embryos: When embryos reach an appropriate stage of development, usually about 3 to 5 days after fertilization, healthcare professionals evaluate their quality. They can select the most promising embryos for transfer.
• Embryo Transfer: Before the embryo transfer process, the medical team prepares the lining of the uterus to accept the embryo. Embryo adhesive, or culture medium supplemented with adhesive component, is used during embryo transfer.
• Embryo Adhesive Application: Embryo adhesive solution is carefully added to the tip of the transfer catheter along with the selected embryo.
• Transfer Procedure: The healthcare provider carefully guides the transfer catheter towards the cervix and uterus, depositing the embryo and adhesive solution.
• Rest and Follow-Up: After the procedure, the patient rests for a short time and is allowed to go home. You will be monitored closely over the following days and weeks to watch for signs of pregnancy.

The use and protocol of embryo adhesive may vary from clinic to clinic and depends on the individual patient situation. Health professionals make decisions about its use based on factors such as the patient’s medical history and the number and quality of embryos available.

Application of embryo glue should only be performed by trained healthcare professionals in a medical setting and should not be attempted outside of a medical setting.

Who Uses Embryo Adhesive?

Embryo glue is primarily used by individuals and couples performing in vitro fertilization (in vitro fertilization) treatments. People who use embryo adhesive can be listed as follows:

• Couples with Infertility Problems: Many couples who cannot conceive naturally may choose IVF as a solution to their fertility problems. In such cases, embryo glue can be used as part of the IVF procedure to increase the chances of successful implantation and pregnancy.
• Women who have experienced recurrent miscarriage: Women who have experienced recurrent miscarriage can use embryo glue to increase their chances of a successful pregnancy during subsequent IVF attempts. This may provide a higher probability of embryo implantation and reduce the risk of miscarriage.
• Patients with a History of Failed IVF Cycles: People who have had multiple unsuccessful IVF cycles may examine the use of embryo glue in their next attempt. This can help increase the chances of implantation and increase the likelihood of a successful pregnancy.
• Individuals with Certain Medical Conditions: Some individuals may have conditions that affect the uterine lining or embryo development, which may negatively affect the success of embryo implantation. Embryo glue may be recommended for people with conditions that affect the uterine lining or embryo development.
• IVF Clinics and Fertility Specialists: Healthcare professionals who apply embryo glue as part of the IVF procedure are IVF clinics and fertility specialists. The decision to use is made based on the patient’s specific circumstances, the number and quality of embryos available, and the patient’s medical history.

It is important to remember that the use of embryo glue is not a standard part of every IVF procedure and each situation is unique. Its use depends on individual patient circumstances and the recommendations of fertility specialists and healthcare professionals.

What is the Content of Embryo Adhesive?

The exact composition of embryo glue may vary slightly between different brands or manufacturers, but generally the main ingredients are:

• Hyaluronan (or Hyaluronic Acid): This is the primary active ingredient in embryo adhesive. Hyaluronan is a natural substance found in the female reproductive tract, especially in the lining of the uterus. It acts as a skeleton that encourages the embryo to attach to the lining of the uterus.
• Culture Media: The solution usually includes the culture medium in which embryos are cultured during IVF procedures. This environment provides the nutrients and conditions necessary for embryo development.
• Other Ingredients: Some versions of embryo glue may contain additional ingredients or supplements such as various salts, amino acids, and proteins to improve the microenvironment to optimize embryo development.

The primary purpose of embryo glue is to create a suitable microenvironment that closely mimics the natural conditions of the uterus. The important thing is that the embryo adhesive and its ingredients may vary between a particular IVF clinic and manufacturer, and constant research is carried out to improve the composition in order to increase its effectiveness. The selection of embryo adhesive and its components is usually made by fertility specialists, based on the patient’s individual circumstances and medical recommendations.

Embryo Adhesive Success Rate

The success rate of embryo adhesive, or any particular assisted reproductive technology (ART) procedure, can vary widely depending on a number of factors, including individual patient characteristics, the cause of infertility, the quality of the embryos, and the expertise of the medical team performing the procedure. Although there is some evidence to suggest that the use of embryo glue may increase the chances of successful implantation and pregnancy compared to standard IVF procedures, the exact success rate may vary. Success rates can range from an improvement of a few percentage points to an improvement in some cases.

The important thing is that success rates are not determined by the use of embryo glue alone. These are influenced by a combination of factors such as the patient’s age, the cause of infertility, the quality of the embryos and the overall health of the patient’s reproductive system. Additionally, the use of embryo glue may increase the chances of implantation, but it does not guarantee a successful pregnancy, and IVF success rates can be affected by a variety of factors, including the patient’s age, the cause of infertility, and the quality of the embryos.

Patients should consult with their healthcare provider to better understand the potential benefits and limitations of using embryo adhesive in their particular situation. They can provide individualized information and guidance based on patients’ medical history and condition. Patients should have a thorough discussion with their healthcare provider to understand the potential benefits and limitations of using embryo adhesive in their particular situation.